School pressure, social media, and the coronavirus pandemic are just some of the factors feeding into the higher rates of anxiety, depression, and other mental health issues for young people. It’s no surprise then that young people might feel that alcohol, vaping, cannabis, and other drugs like fentanyl are a good idea to provide some relief. While understandable, this behavior can damage a developing brain and affect mental health. In the worst-case scenario, accidental drug overdose can kill. How can parents and guardians look out for the signs of substance use, work to prevent substance use, and respond appropriately?